![]() From that point on, Butler began taking acting seriously as a career. His friend on the show, Lindsey Shaw, introduced him to her manager, Pat Cutler, who signed him and launched his career. In 2005, after working as an extra on several television series, including Unfabulous and Drake and Josh, Butler landed his first regular job as a background actor playing the role of Zippy Brewster for two seasons on Nickelodeon's Ned's Declassified School Survival Guide. He continued his homeschooling until the tenth grade and later passed the CHSPE, the state's high school equivalency diploma.Ĭareer 2005–2011: Early career in teen sitcoms ![]() īutler attended public school until the seventh grade, when he left to be homeschooled to better accommodate his work schedule. He found that he enjoyed it and soon began taking acting classes. When Butler was thirteen, he was approached by a representative from a background acting management company at the Orange County Fair who helped him get started in the entertainment industry. He has an older sister, Ashley (born in 1986), who worked as a background actor alongside him on Ned's Declassified School Survival Guide. Butler made his Broadway debut in the 2018 revival of The Iceman Cometh and played Tex Watson in Quentin Tarantino's film Once Upon a Time in Hollywood (2019).īutler was born on August 17, 1991, in Anaheim, California, the son of Lori Anne (née Howell), an aesthetician, and David Butler. He gained recognition for starring in The Carrie Diaries (2013–2014) and The Shannara Chronicles (2016–2017). īutler began his career on television, first in roles on the Disney Channel and Nickelodeon and later on teen dramas, including recurring parts on The CW's Life Unexpected (2010–2011) and Switched at Birth (2011–2012). Time magazine named him one of the 100 most influential people in the world in 2023. He is known for portraying Elvis Presley in the musical biopic Elvis (2022), for which he won a Golden Globe Award and a BAFTA, in addition to a nomination for the Academy Award for Best Actor. All rights reserved.Austin Robert Butler (born August 17, 1991) is an American actor. ![]() These results suggest potential novel therapeutic targets for C9ORF72-ALS/FTD.ĪLS C9ORF72 DPR FTD Hsp90 Mtk TopoII antimicrobial peptide neurodegeneration poly(GR).Ĭopyright © 2023 The Author(s). TopoII knockdown also suppresses poly(GR) toxicity in Drosophila and improves survival of C9ORF72 iPSC-derived motor neurons. Topoisomerase II (TopoII) regulates poly(GR)-induced upregulation of Hsp90 and Mtk. Hsp90 knockdown partially rescues both poly(GR) toxicity in flies and neurodegeneration in C9ORF72 motor neurons derived from induced pluripotent stem cells (iPSCs). These findings suggest a cell-autonomous role of Mtk in neurodegeneration. Mtk knockdown in the fly eye or in all neurons suppresses poly(GR) neurotoxicity. ![]() In an RNA-seq analysis of poly(GR) toxicity in Drosophila, we found that several antimicrobial peptide genes, such as metchnikowin (Mtk), and heat shock protein (Hsp) genes are activated. Repeat RNAs can be translated into dipeptide repeat proteins, including poly(GR), whose mechanisms of action remain largely unknown. GGGGCC repeat expansion in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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